Metabolic Health 

The rise of drugs like GLP-1 receptor agonists —including semaglutide and tirzepatide—has transformed obesity treatment. But alongside their success, a persistent concern has emerged: Are we trading fat loss for muscle loss? A new study published in Cell Reports Medicine  offers a more reassuring—and nuanced—answer. The Concern: “Skinny Fat” from GLP-1 Drugs Rapid weight loss, especially from pharmacological interventions, has historically been associated with: Loss of lean b

A recent review paper suggests that insulin, rather than insulin resistance, is a key driver of obesity. This thinking places a significant burden upon #suger as a key driver for insulin induced obesity. The authors state the following - Reducing refined carbohydrates Managing glycaemic load The “hyperinsulinaemia causes obesity” model is compelling, but it risks oversimplifying a tightly coupled system. An alternative interpretation is: Insulin resistance comes first. Hyperi

For decades, obesity has been framed as a simple imbalance between calories consumed and calories burned. But emerging research published in Nature Reviews Endocrinology challenges this conventional narrative. Instead of overeating being the root cause, the spotlight is shifting toward a deeper metabolic driver: hyperinsulinaemia—chronically elevated insulin levels. The Paradigm Shift: From Calories to Hormones Traditional models of obesity emphasize behavior—diet, physical a