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Beyond Blood Sugar: Why the Next Generation of Obesity Medicines May Go Beyond GLP-1
For years, we have tended to think about metabolic disease through one main lens: blood sugar. If glucose is too high, we lower it. If HbA1c improves, the treatment is working. But obesity is much more complicated than that. Someone can live with significant obesity without having diabetes. They can have insulin resistance, fatty liver disease, high blood pressure, sleep apnoea and increased cardiovascular risk while their blood glucose still looks relatively normal. So perh


What Happens When You Stop Taking GLP-1 Weight Loss Medication?
GLP-1 medications such as semaglutide (Wegovy®) and tirzepatide (Mounjaro®) have transformed obesity treatment, helping many people achieve significant and sustained weight loss for the first time. But one question comes up in almost every time I discuss this topic: “What happens when I stop taking it?” The short answer is that it depends—but for many people, weight regain is common. That doesn’t mean the medication has “failed”, nor does it mean you’ve done anything wrong. I


Carbohydrate (Glucose) Metabolism and Aging: What’s the Connection?
Carbohydrates (CHO) are a fundamental energy source, supporting cellular function, physical activity, and metabolic processes. However, a growing body of research suggests that chronically elevated carbohydrate metabolism—particularly in the context of sustained high glucose availability—can influence key biological pathways linked to aging. One central mechanism involves mitochondrial function and oxidative stress. During carbohydrate metabolism, glucose is processed through
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Rethinking Obesity: Is Insulin the Real Culprit?
For decades, obesity has been framed as a simple imbalance between calories consumed and calories burned. But emerging research published in Nature Reviews Endocrinology challenges this conventional narrative. Instead of overeating being the root cause, the spotlight is shifting toward a deeper metabolic driver: hyperinsulinaemia—chronically elevated insulin levels. The Paradigm Shift: From Calories to Hormones Traditional models of obesity emphasize behavior—diet, physical a
Metabolic-Health@outlook.com
Mar 213 min read


How Fatigue and Insulin Resistance Are Linked
Are you feeling tired all of the time? In very simple and quick terms, insulin resistance affects your energy Metabolism. Insulin...
Metabolic-Health@outlook.com
Jul 11, 20252 min read


Common Negative Effects of GLP-1 Injections - Is semaglutide really the quick fix?
GLP-1 receptor agonists (e.g., semaglutide, liraglutide, dulaglutide) are widely used for type 2 diabetes and obesity. While effective...
Metabolic-Health@outlook.com
May 19, 20252 min read


"Can Myo-Inositol Really Improve Insulin Resistance? Here's What You Need to Know"
Dr Richard Mackenzie
Metabolic-Health@outlook.com
May 25, 20242 min read


Eat protein in moderation, from whole foods and not processed supplements.
A good friend and leading researcher in the field of protein metabolism (Dr Burd) has published a number of studies that show the...
Metabolic-Health@outlook.com
Apr 25, 20243 min read


Avocados may have surprising impact on women's belly fat
https://www.independent.co.uk/tv/lifestyle/avocado-women-belly-fat-study-v547c1e20 n avocado a day could help redistribute belly fat in...
Metabolic-Health@outlook.com
Sep 7, 20213 min read

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