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Metabolic Health
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What Happens When You Stop Taking GLP-1 Weight Loss Medication?
GLP-1 medications such as semaglutide (Wegovy®) and tirzepatide (Mounjaro®) have transformed obesity treatment, helping many people achieve significant and sustained weight loss for the first time. But one question comes up in almost every time I discuss this topic: “What happens when I stop taking it?” The short answer is that it depends—but for many people, weight regain is common. That doesn’t mean the medication has “failed”, nor does it mean you’ve done anything wrong. I


Carbohydrate (Glucose) Metabolism and Aging: What’s the Connection?
Carbohydrates (CHO) are a fundamental energy source, supporting cellular function, physical activity, and metabolic processes. However, a growing body of research suggests that chronically elevated carbohydrate metabolism—particularly in the context of sustained high glucose availability—can influence key biological pathways linked to aging. One central mechanism involves mitochondrial function and oxidative stress. During carbohydrate metabolism, glucose is processed through


Do Weight Loss Drugs Cost You Muscle? New Research Challenges a Growing Concern
The rise of drugs like GLP-1 receptor agonists —including semaglutide and tirzepatide—has transformed obesity treatment. But alongside their success, a persistent concern has emerged: Are we trading fat loss for muscle loss? A new study published in Cell Reports Medicine offers a more reassuring—and nuanced—answer. The Concern: “Skinny Fat” from GLP-1 Drugs Rapid weight loss, especially from pharmacological interventions, has historically been associated with: Loss of lean b
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Insulin resistance comes first. Hyperinsulinaemia follows. Obesity emerges downstream.
A recent review paper suggests that insulin, rather than insulin resistance, is a key driver of obesity. This thinking places a significant burden upon #suger as a key driver for insulin induced obesity. The authors state the following - Reducing refined carbohydrates Managing glycaemic load The “hyperinsulinaemia causes obesity” model is compelling, but it risks oversimplifying a tightly coupled system. An alternative interpretation is: Insulin resistance comes first. Hyperi
Metabolic-Health@outlook.com
Mar 212 min read


Rethinking Obesity: Is Insulin the Real Culprit?
For decades, obesity has been framed as a simple imbalance between calories consumed and calories burned. But emerging research published in Nature Reviews Endocrinology challenges this conventional narrative. Instead of overeating being the root cause, the spotlight is shifting toward a deeper metabolic driver: hyperinsulinaemia—chronically elevated insulin levels. The Paradigm Shift: From Calories to Hormones Traditional models of obesity emphasize behavior—diet, physical a
Metabolic-Health@outlook.com
Mar 213 min read


How stress and cortisol contribute to infertility
How Stress and Cortisol Influence Infertility and IVF Outcomes: What Recent Research Shows Infertility is a deeply personal and often stressful experience for couples trying to conceive. For many women, the emotional toll of infertility compounds the physical demands of fertility treatments such as in vitro fertilization (IVF). Recent research published in Frontiers in Endocrinology has shed new light on how dysregulation of the stress hormone cortisol — particularly when in
Metabolic-Health@outlook.com
Jan 135 min read

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